Home » Seven Things You Most Likely Didn’t Know About Effects of Modalert on Oral Contraceptives

Seven Things You Most Likely Didn’t Know About Effects of Modalert on Oral Contraceptives

by ameliabell

Since July 2002, modafinil has been available in Australia as a wakefulness-promoting agent. Modafinil enhances alertness through an as-yet-unidentified mechanism. In people with narcolepsy, it dramatically enhances daytime sleep latency and lowers excessive daytime sleepiness (EDS) when compared to placebo.

The medication, however, has little effect on cataplexy (sudden loss of muscle function while conscious). Despite the lack of directly comparable data, modafinil has advantages over amphetamines and methylphenidate in patients with narcolepsy due to its lack of rebound effects following medication cessation and its low potential for addiction.

The Therapeutic Goods Administration (TGA), which is part of the Australian Government’s Department of Health, is in charge of regulating therapeutic goods such as prescription medicines, vaccinations, sunscreens, vitamins and minerals, medical devices, and blood and blood products.

The TGA came to the following conclusion:

  • For the indications of improving wakefulness in patients with excessive daytime sleepiness associated with narcolepsy and in patients with obstructive sleep apnea/hypopnea syndrome as an adjuvant to continuous positive airway pressure, (CPAP) the benefits of modafinil continued to outweigh the dangers
  • The rationale for treating excessive drowsiness associated with moderate-to-severe chronic shift work sleep disorder should be amended to include only patients who have failed or are inappropriately responding to non-pharmacological therapies (e.g. planned napping).

NOTE: Modalert 200 can help with the symptom of excessive sleepiness, but it doesn’t address the cause. Modafinil should only be used as an addition to CPAP when used to improve wakefulness in patients with obstructive sleep apnea/hypopnea syndrome.

Which medications or supplements interact with Modalert?

The activity of enzymes in the liver that metabolize (eliminate) other medications can be reduced or increased by modafinil. This can lead to lower levels of some medications, reducing their effectiveness, and higher levels of other drugs, causing toxicity. If you’re using modafinil with any of these medications, you should keep an eye on it. Cyclosporine (Sandimmune), theophylline, and hormonal contraceptives such as progestin-only or estrogen and progesterone-containing medications (for example, Micronor, Ortho-Novum 1/50) may have reduced effectiveness when combined with modafinil.

During modafinil treatment, other hormonal contraceptives or an extra non-drug type of contraception should be examined, and treatment should be continued for one month after modafinil therapy ceases (since the effects of modafinil on contraceptive hormones may continue for several weeks). Modafinil has an effect on hormonal contraceptives when they are administered by mouth, patch, or implant.

What is the effect of Modalert on oral contraceptives concluded by Central European University (CEU)?

Drug interactions between ethinylestradiol (oral contraceptive) and Modafinil have been observed, most likely through the CYP3A4 enzyme route, according to Central European University. This interaction will probably have an impact on progestogens as well. As a result, modafinil may diminish the effectiveness of combined hormonal contraceptives (such as the pill, patch, and vaginal ring), progestogen-only pills, and subdermal implants. To ensure contraceptive efficacy, women taking modafinil should be advised to adopt techniques that are not impacted by enzyme-inducing medicines, such as a copper intrauterine device (Cu-IUD), levonorgestrel-releasing intrauterine system (LNG-IUS), or depot medroxyprogesterone acetate (DMPA).

According to the CEU, healthcare providers should inform women who are using hormonal contraception or who are taking modafinil off-label about the potential influence on contraceptive efficacy and counsel them on the best methods of contraception to utilize.

 

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